Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check out reviews of Santo Antonio hotels guests love
Sé Boutique Hotel
10/10 Excellent
"Lovely small central hotel . Perfect for accessing the old town. If you don’t need an outdoor pool and like to be close to town this hotel is a good option."
"I stayed at Saccharum Resort & Spa and while the stunning views are an obvious highlight, what really stood out to me was the hotel’s design.
It honours its past as a former sugar cane factory — with original machinery cleverly integrated into the lobby and hallways. Think softened brutalism: raw textures balanced by warm materials, plenty of natural light, and an organic palette that ties everything back to the surrounding mountains. The attention to detail is impressive!!!
Our room was gorgeous — it overlooked the ocean, and with the mountains rising just beside us, we felt perfectly tucked between both. A rare and calming combination.
Even when the hotel was busy, it never felt crowded. There are multiple lounging areas, and we always found a spot to relax. The pools were a highlight — especially the indoor one, which is beautifully designed, heated, and great for cooler days or when you want a break from the sun. The large window looking out at the mountains makes being indoors feel like part of the experience.
The food was varied and healthy, and we appreciated how the hotel clearly communicated when breakfast would be busy — a small but thoughtful detail that made a difference. And if you’re looking for more variety, there are plenty of restaurants nearby.
The staff were consistently courteous, multilingual, and genuinely helpful — from check-in to daily service.
Saccharum strikes a rare balance: thoughtful design, warm hospitality, and a peaceful atmosphere."
"Wow! Property is beautiful, but the service was incredible! The team there DEFINITELY deserves the previous awards they’ve won! I’ve only stayed at one other property in my entire 57 years that I would say might be comparable to the service we received at the Vine! It made our trip! THANK YOU!"
"Had an amazing stay at this hotel! I particularly loved my room - I had a superior room which was very big and spacious and had a balcony with such an incredible view. I also loved the swimming pool (both indoor and outdoor). The reception staff were super friendly who made me feel happy and welcomed. A particular shout out to Katerina at the reception desk who showed me such great hospitality. I’d definitely stay here again. "
Can I book a refundable accommodation option in Santo Antonio?
If you want the flexibility to change your plans to Santo Antonio, most hotels offer refundable* rates that you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in Santo Antonio if I want a holiday rental instead of a hotel?
If you're looking for a good alternative to a hotel, look over our selection of 18 holiday homes. You can also book one of 54 apartments or 20 villas.
What will the weather in Santo Antonio be like during my visit?
August and July are typically the warmest months in Santo Antonio, when the average temperature is 20°C. February and March are the coldest months, when the average temperature is 14°C. December and November are the months with the most rain.
Why should I book my Santo Antonio hotel with Hotels.com?
There are lots of reasons to book your Santo Antonio trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.
Find out more about Santo Antonio
Find out more about Santo Antonio
If you're looking for a place to get away, look no further than Santo Antonio. Whether you're planning to stay for a night or for the week, the area around Santo Antonio has accommodation options to fit every need. Search for hotels in Santo Antonio with Hotels.com by checking our online map. Our map displays the areas and neighbourhoods around all Santo Antonio hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Santo Antonio hotel deals are here with our lowest price guarantee.
